Clinical and Data Science

Our research addresses sex- and gender-specific differences through three complementary strategies: analysis of existing international datasets, visualization of complex patterns across large cohorts, and generation of new data from our clinical work. This combination bridges global perspectives with local clinical insight to enable immediately actionable therapy optimization and has led to publications in high-impact journals as well as contributions to policy documents, including reports by the European Commission. The result: more precise, gender-equitable treatment strategies reaching patients nationally and internationally.

Most recently, in an interdisciplinary collaboration with our partners at the University of Mannheim, using large-scale datasets with millions of observations, we showed that biomedical research activity remains systematically misaligned with disease burden across conditions and over time (Schmallenbach et al, Nature Medicine, 2025). Extending this systems perspective to questions of sex/gender in medicine and science, we have previously studied sex/gender representation and analytical integration in clinical trials (Bley et al., Clin Res Cardiology, 2025), sex/gender differences in longitudinal productivity patterns (Lerchenmüller et al., Circulation, 2018), disparities in the attention paid to research (Lerchenmüller et al., Comm Biology, 2023), and the impact of the COVID-19 pandemic on women and men scientists (Lerchenmüller et al., BMJ open, 2021).
 

• Bley M, Mathez L, Menz S, Stephan I, Regitz-Zagrosek V, Lerchenmueller MJ, Lerchenmüller C. Consideration of sex/gender aspects in cardiovascular clinical trials.
  Clin Res Cardiol. 2025 Nov 26. doi: 10.1007/s00392-025-02793-3. Epub ahead of print. PMID: 41296008. 

• Schmallenbach L, Bley M, Bärnighausen TW, Sugimoto CR, Lerchenmüller C, Lerchenmueller MJ. Global distribution of research efforts, disease burden, and impact of US public funding withdrawal. 
  Nat Med. 2025 Aug 27. doi: 10.1038/s41591-025-03923-0. Epub ahead of print. PMID: 40866582.

• Preprint: Egger I, Weidlinger S, Zdanowicz J, Kublickiene K, Nater C, Streit S, Moor J. Parenthood, Caregiving and Female Fertility Among General Internal Medicine Physicians in Switzerland.Preprint MedRxiv. 2025 September 12.
  doi: 10.1101/2025.09.10.25335526  

• Preprint: Leitner T, Egger I, Streit S, Moor J. Sex-stratified analysis of factors associated with attrition intent from the General Internal Medicine physician workforce in Switzerland.Preprint MedRxiv. 2025 September 07.
  doi: 10.1101/2025.09.04.25335096  

• Preprint: Egger I, Nater C, Streit S, Moor J. Sex differences in personal and work-related factors associated with impaired mental well-being among Swiss General Internal Medicine physicians.Preprint MedRxiv. 2025 August 29.
  doi: 10.1101/2025.08.27.25334568  

• Preprint: Wassner O, Nater C, Barbier JM, Streit S, Moor J. The Prevalence of Sexual Harassment in Internal Medicine in Switzerland
  Preprint MedRxiv. 2025 August 28.
  doi: 10.1101/2025.08.27.25334541   

• Preprint: Moor J, Woodtli L, Baumgartner C, Kublickiene K, Streit S, Nater C. Factors Associated with Career Ambitions in General Internal Medicine: Insights Into Gender Disparities in Leadership Aspirations.Preprint: MedRxiv. 2025 May 19.
  doi: 10.1101/2025.05.18.25327847  

• Moor J, Toepfner N, von Meißner WCG, Berner R, Moor MB, Kublickiene K, Strumann C, Chao CM. Sex differences in symptoms following the administration of BNT162b2 mRNA COVID-19 vaccine in children below 5 years of age in Germany (CoVacU5): a retrospective cohort study.Biol Sex Differ. 2024 Sep 26;15(1):74. doi: 10.1186/s13293-024-00651-x. PMID: 39327617; PMCID: PMC11426002.  

• Moor J, Kuhne M, Moschovitis G, Kobza R, Netzer S, Auricchio A, Beer JH, Bonati L, Reichlin T, Conen D, Osswald S, Rodondi N, Clair C, Baumgartner C, Aubert CE. Sex-specific association of cardiovascular drug doses with adverse outcomes in atrial fibrillation.
  Open Heart. 2024 Aug 12;11(2):e002720. doi: 10.1136/openhrt-2024-002720. PMID: 39134361; PMCID: PMC11331917.  

• Jungo KT, Deml MJ, Schalbetter F, Moor J, Feller M, Lüthold RV, Huibers CJA, Sallevelt BTGM, Meulendijk MC, Spruit M, Schwenkglenks M, Rodondi N, Streit S. A mixed methods analysis of the medication review intervention centered around the use of the 'Systematic Tool to Reduce Inappropriate Prescribing' Assistant (STRIPA) in Swiss primary care practices.BMC Health Serv Res. 2024 Mar 18;24(1):350. doi: 10.1186/s12913-024-10773-y. Erratum in: BMC Health Serv Res. 2024 Apr 2;24(1):413. doi: 10.1186/s12913-024-10896-2. PMID: 38500163; PMCID: PMC10949561.  

• Darphin X, Moor J, da Silva CE, Richters A, Özdemir BC. Awareness of the impact of sex and gender in the disease risk and outcomes in hematology and medical oncology-a survey of Swiss clinicians. Cancer Rep (Hoboken). 2024 Feb;7(2):e1961. doi: 10.1002/cnr2.1961. Epub 2024 Jan 23. PMID: 38258483; PMCID: PMC10849995. 

• Lerchenmueller MJ, Schmallenbach L, Bley M, Lerchenmüller C. Gender disparities in altmetric attention scores for cardiovascular research. 
  Commun Biol. 2023 Jul 17;6(1):741. doi: 10.1038/s42003-023-05058-9. PMID: 37460580; PMCID: PMC10352379. 

• Lerchenmüller C, Zelarayan L, Streckfuss-Bömeke K, Gimenez MR, Schnabel R, Hashemi D, Baldus S, Rudolph TK, Morbach C. Moving toward gender equity in the cardiology and cardiovascular research workforce in Germany: a report from the German Cardiac Society.Eur Heart J Open. 2023 Mar 29;3(2):oead034. doi: 10.1093/ehjopen/oead034. PMID: 37090057; PMCID: PMC10114529. 

• Toepfner N, von Meißner WCG, Strumann C, Drinka D, Stuppe D, Jorczyk M, Moor J, Püschel J, Liss M, von Poblotzki E, Berner R, Moor MB, Chao CM. Comparative Safety of the BNT162b2 Messenger RNA COVID-19 Vaccine vs Other Approved Vaccines in Children Younger Than 5 Years. JAMA Netw Open. 2022 Oct 3;5(10):e2237140. doi: 10.1001/jamanetworkopen.2022.37140. PMID: 36255723; PMCID: PMC9579908.  

• Moor J, Baumgartner C, Méan M, Stalder O, Limacher A, Rodondi N, Aujesky D. Validation of the 2019 European Society of Cardiology Risk Stratification Algorithm for Pulmonary Embolism in Normotensive Elderly Patients. Thromb Haemost. 2021 Dec;121(12):1660-1667. doi: 10.1055/a-1475-2263. Epub 2021 May 28. PMID: 33823559.  

• Lerchenmüller C, Schmallenbach L, Jena AB, Lerchenmueller MJ. Longitudinal analyses of gender differences in first authorship publications related to COVID-19.
  BMJ Open. 2021 Apr 5;11(4):e045176. doi: 10.1136/bmjopen-2020-045176. PMID: 33820790; PMCID: PMC8025238. 

• Baumgartner C, Klok FA, Carrier M, Limacher A, Moor J, Righini M, Beer JH, Peluso M, Rakovic D, Huisman MV, Aujesky D. Clinical Surveillance vs. Anticoagulation For low-risk patiEnts with isolated SubSegmental Pulmonary Embolism: protocol for a multicentre randomised placebo-controlled non-inferiority trial (SAFE-SSPE).BMJ Open. 2020 Nov 19;10(11):e040151. doi: 10.1136/bmjopen-2020-040151. PMID: 33444199; PMCID: PMC7678381.  

• Wüthrich F, Pavlidou A, Stegmayer K, Eisenhardt S, Moor J, Schäppi L, Vanbellingen T, Bohlhalter S, Walther S. Nonverbal communication remains untouched: No beneficial effect of symptomatic improvement on poor gesture performance in schizophrenia.Schizophr Res. 2020 Sep;223:258-264. doi: 10.1016/j.schres.2020.08.013. Epub 2020 Sep 1. PMID: 32883557; PMCID: PMC7952214. 

• Lerchenmüller C, Hilfiker-Kleiner D. Cardiology and cardiovascular research in Germany: 5 years of gender demographics.
  Clin Res Cardiol. 2019 Feb;108(2):218-220. doi: 10.1007/s00392-018-1335-y. Epub 2018 Jul 26. PMID: 30051180. 

• Lerchenmüller C, Lerchenmueller MJ, Sorenson O. Long-Term Analysis of Sex Differences in Prestigious Authorships in Cardiovascular Research Supported by the National Institutes of Health.Circulation. 2018 Feb 20;137(8):880-882. doi: 10.1161/CIRCULATIONAHA.117.032325. PMID: 29459476. 

• Stegmayer K, Moor J, Vanbellingen T, Bohlhalter S, Müri RM, Strik W, Walther S. Gesture Performance in First- and Multiple-Episode Patients with Schizophrenia Spectrum Disorders. Neuropsychobiology. 2016;73(4):201-8. doi: 10.1159/000446116. Epub 2016 May 28. PMID: 27229523.  

• Stegmayer K, Bohlhalter S, Vanbellingen T, Federspiel A, Moor J, Wiest R, Müri R, Strik W, Walther S. Structural brain correlates of defective gesture performance in schizophrenia.
  Cortex. 2016 May;78:125-137. doi: 10.1016/j.cortex.2016.02.014. Epub 2016 Mar 10. PMID: 27038858.  

• Walther S, Stegmayer K, Sulzbacher J, Vanbellingen T, Müri R, Strik W, Bohlhalter S. Nonverbal social communication and gesture control in schizophrenia.
  Schizophr Bull. 2015 Mar;41(2):338-45. doi: 10.1093/schbul/sbu222. Epub 2015 Feb 1. PMID: 25646526; PMCID: PMC4332963.