Molekulare Kardiologie

Lerchenmüller C, Hastings MH, Rabolli CP, Betge F, Roshan M, Liu LX, Liu X, Heß C, Roh J, Platt C, Bezzerides V, Busch M, Katus HA, Frey N, Most P, Rosenzweig A. CITED4 gene therapy alters maladaptive cardiac remodeling after ischemia-reperfusion injury. Molecular Therapy 2024, Volume 32, Issue 10, 2024,Pages 3683-3694

Liu X, Li H, Hastings MH, Xiao C, Damilano F, Platt C, Lerchenmüller C, Zhu H, Wie XP, Yeri A, Most P, Rosenzweig A. miR-222 inhibits pathological cardiac hypertrophy and heart failure. Cardiovascular Research 2024 Mar 14;120(3):262-272

Roh JD, Castro C, Yu A, Rana S, Shahul S, Gray KJ, Honigberg MC, Ricke-Hoch M, Iwamoto Y, Yeri A, Kitchen R, Guerra J, Hobson R, Chaudhri V, Chang B, Sarma A, Lerchenmüller C, Al Sayed ZR, Diaz Verdugo C, Xia P, Skarbianskis N, Zeisel A, Bauersachs J, Kirkland JL, Karumanchi SA, Gorcsan J, Sugahara M, Damp J, Hanley-Yanez K, Ellinor PT, Aranzy Z, McNamara DM; IPAC Investigators; Hilfiker-Kleiner D, Rosenzweig A. Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Science Translational Medicine 2024 Apr 17;16(743):eadi0077 

Lerchenmüller C*, Vujic A*, Mittag S, Wang A, Rabolli CP, Heß C, Betge F, Rangrez AY, Chaklader M, Guillermier C, Gyngard F, Roh JD, Li H, Steinhauser ML, Frey N, Rothermel B, Dieterich C, Rosenzweig A, Lee RT (2022). Restoration of Cardiomyogenesis in Aged Mouse Hearts by Voluntary Exercise. Circulation 2022;0:10.1161/CIRCULATIONAHA.121.057276*contributed equally

Lerchenmüller C, Rabolli CP, Yeri AS, Kitchen R, Salvador AM, Liu LX, Ziegler O, Danielson K, Platt C, Shah R, Damilano F, Kundu P, Riechert E, Katus HA, Saffitz JE, Keshishian H, Carr S, Bezzerides VJ, Das S, Rosenzweig A (2020). CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circulation Research 127:631-646, 2020

Roh JD, Houstis N, Yu A, Chang B, Yeri A, Li H, Hobson R, Lerchenmüller C, Vujic A, Chaudhari V, Damilano F, Platt C, Zlotoff D, Lee RT, Shah R, Jerosch-Herold M and Rosenzweig A (2020). Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice. Aging Cell 19:e13159, 2020

Vujic A*, Lerchenmüller C*, Wu TD, Guillermier C, Rabolli CP, Gonzalez E, Senyo SE, Liu X, Guerquin-Kern JL, Steinhauser ML, Lee RT, Rosenzweig A (2018). Exercise induces new cardiomyocyte generation in the adult mammalian heart. Nature Communications 9:1659, 2018 *contributed equally, Top 50 Life and Biological Sciences Nature Communications 2018

Lerchenmüller C#, Heissenberg J, Damilano F, Bezzerides J, Krämer I, Bochaton-Piallat ML, Hirschberg K, Busch M, Katus HA, Peppel K, Rosenzweig A, Busch H, Boerries M#, Most P (2016). S100A6 regulates endothelial cell cycle progression by attenuating antiproliferative STAT1 signaling. Arteriosclerosis, Thrombosis and Vascular Biology 36:1854-67, 2016  #corresponding authors

Bezzerides VJ, Platt C, Lerchenmüller C, Paruchuri K, Oh NL, Xiao C, Cao Y, Mann N, Spiegelman BM and Rosenzweig A. CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury. JCI insight 1:e85904, 2016

Sen A, Ren S, Lerchenmüller C, Sun J, Weiss N, Most P, Peppel K (2013). MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. Plos One Nov 11;8(11):e78684. doi: 10.1371/journal.pone.0078684

Most P*, Lerchenmüller C*, Rengo G, Mahlmann A, Ritterhoff J, Rohde D, Goodman C, Busch CJ, Laube F, Heissenberg J, Pleger ST, Weiss N, Koch WJ, Katus HA, Peppel K. S100A1 Deficiency Impairs Post-Ischemic Angiogenesis via Compromised Proangiogenic Endothelial Cell Function and Nitric Oxide Synthase Regulation. Circulation Research 112:66-78, 2013  *contributed equally

Brinks H, Rohde D, Voelkers M, Qiu G, Pleger ST, Herzog N, Rabinowitz J, Ruhparwar A, Silvestry S, Lerchenmüller C, Mather PJ, Eckhart AD, Katus HA, Carrel T, Koch WJ and Most P. S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes. J Am Coll Cardiol 58:966-73, 2011

Hastings M, Zhou Q, Wu C, Shabani P, Huang S, Yu, X, Singh AP, Guseh JS, Li H,  Lerchenmüller C, Rosenzweig A. Cardiac Aging: From Hallmarks to Therapeutic Opportunities (Cardiovascular Research 2024 Jun 26:cvae124. doi: 10.1093/cvr/cvae124. Epub ahead of print. PMID: 38918884)

 Hastings MH, Castro C, Freeman R, Kadir AA, Lerchenmüller C, Li H, Rhee J, Roh JD, Singh AP, Chao W, Xia P, Zhou Q, Xiao J, Rosenzweig A. Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise. JACC: Basic to Translational Science 2023 Oct 18;9(4):535-552

 Lerchenmüller C, Rosenzweig A. Mechanisms of Exercise-Induced Cardiac Growth. Drug Discovery Today 19:1003-9, 2014 

 Kraus C, Rohde D, Weidenhammer C, Qiu G, Pleger ST, Völkers M, Börries M, Most P.                                                         S100A1 in cardiovascular health and disease: Closing the gap between basic science and clinical therapy. Journal of Molecular and Cellular Cardiology 2009 Oct;47(4):445-55.